Exosome component 3

Exosome component 3

PDB rendering based on 2nn6.

Available structures
PDB	2nn6

Identifiers

EXOSC3; MGC15120; MGC723; RP11-3J10.8; RRP40; Rrp40p; bA3J10.7; hRrp-40; hRrp40p; p10

External IDs

OMIM: 606489 MGI: 1913612 HomoloGene: 6867 GeneCards: EXOSC3 Gene

Gene Ontology
Molecular function	• 3'-5'-exoribonuclease activity • RNA binding • exoribonuclease activity • protein binding
Cellular component	• nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) • nucleus • nucleolus • cytoplasm • cytosol • transcriptionally active chromatin
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • rRNA processing • RNA metabolic process • mRNA metabolic process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • DNA deamination • isotype switching • CUT catabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000107371

ENSMUSG00000028322

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
37.77 – 37.8 Mb

Chr 4:
45.33 – 45.36 Mb

PubMed search

Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosome complex.^[1]

References

^ "Entrez Gene: EXOSC3 exosome component 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51010.

Further reading

Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316947.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310876.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=83843.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gherzi R, Lee KY, Briata P, et al. (2004). "A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.". Mol. Cell 14 (5): 571–83. doi:10.1016/j.molcel.2004.05.002. PMID 15175153.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

2nn6: Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40